Pathology I
Outline
Pathological diagnosis is based on the principle that abnormalities in function are reflected in morphology, but the molecular mechanisms linking function, morphology, and dynamics have not yet been clarified. In our laboratory, we focus on the specific morphology and dynamics observed in diseases, and aim to clarify the behavior of cells in vivo by live imaging in order to establish the basis for new therapeutic methods. We have been analyzing each process of cancer invasion and metastasis separately. We are now focusing on the following 3 points: 1) Verifying the go-or-grow hypothesis of colon cancer cells at the invasive border by immunostaining surgical specimens. 2) Analyzing the role of cholesterol in the growth of cancer cells in the liver, the main metastatic site of colon cancer. 3) Establishment of in vitro muscle-layer culture to observe invasive cell dynamics.
e-mail: pathol1@kanazawa-med.ac.jp
Faculty
Professor and Chair
Assistant Professor
Research Assistant
NAKAYAMA Asami
Research Assistant
TANIGUCHI Kumiko
Research Assistant
MIZUOCHI Hiroko
Research Achievements
Kin R*., Hoshi D*., (*Co-fast authors) Fujita H., Kosaka T., Takamura H., Kiyokawa E*.: Prognostic significance of p16, p21 and Ki67 expression at the invasive front of colorectal cancers. Pathol Int.: 73(2), 881-90, 2023
Kiyokawa E, Shoji H., Daikoku, T.: The suppression of DOCK family members by their specific inhibitors induces the cell fusion of human trophoblastic cells. Biochem Biophys Res Commun.: 529(4), 1173-1179, 2020
Aikawa A., Fujita H., Kosaka T., Minato H., Kiyokawa E.: The clinicopathological significance of heterogeneic Ezrin expression in PDCs of colorectal cancers. Can Sci.: 110(8), 2667-2675, 2019.
Hirata E*., Ichikawa T*.,(*Co-fast authors) Horike S., Kiyokawa E.: Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro. Can Sci.: 109(12), 4045-4055, 2018.
Takeda H., Kiyokawa E.: Activation of Erk in ileal epithelial cells engaged in ischemic-injury repair. Sci Rep, 7(1):16469, 2017
External Research Funding
Grants-in-Aid for Scientific Research (C) ＜KAKENHI Kiban C＞ (Kiyokawa)
2017-19 Metabolism and lymphatic invasion of the cell clusters at the colon cancer invasive front
Grant-in-Aid for Challenging Exploratory Research (Kiyokawa)
2016 Fetal microchimerism and cancer
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) (Kiyokawa9
2014-15 Rotation of the glands in vessels and invasion/metastasis.
2012-13 Establishment of organoid culture and fluorescent imaging system to model cancer invasion.