色多多视频

Departments

総合医学研究所研究室一覧のイメージ
Medical Research Institute - Department of Advanced Medicine

Division of AGEs Research (Advanced Glycation End-products Research)

Outline

Advanced glycation end-products (AGEs) are formed through non-enzymatic glycation reactions between sugars and proteins. They are considered key contributors to the onset and progression of lifestyle-related diseases. AGEs are generated via various pathways in the body, with those derived from glyceraldehyde—a tricarbohydrate intermediate of glucose and fructose metabolism—exhibiting strong cytotoxic properties. This has led to the proposal of the concept of "toxic AGEs (TAGE)." TAGE is strongly associated with the onset and progression of diabetes and its vascular complications, as well as with several other conditions, including metabolic dysfunction-associated steatohepatitis (MASH), cardiovascular disease, cancer, infertility, and Alzheimer's disease. Reducing the impact of TAGE is now recognized as a potential strategy for preventing and treating lifestyle-related diseases. Additionally, fluctuations in blood TAGE levels have been identified as a promising biomarker for assessing the effectiveness of prevention, early diagnosis, and treatment of lifestyle-related diseases, including pre-disease states, regardless of diabetic status. Understanding blood TAGE levels could enable the early prediction of disease onset and progression, contributing to disease prevention and the extension of healthy life expectancy.

Faculty

Associate Professor

Professor Emeritus?Professor (Adjunct)

Senior Assistant Professor

Research Achievements

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