Division of AGEs Research (Advanced Glycation End-products Research)
Outline
Advanced glycation end-products (AGEs) are formed through non-enzymatic glycation reactions between sugars and proteins. They are considered key contributors to the onset and progression of lifestyle-related diseases. AGEs are generated via various pathways in the body, with those derived from glyceraldehyde—a tricarbohydrate intermediate of glucose and fructose metabolism—exhibiting strong cytotoxic properties. This has led to the proposal of the concept of "toxic AGEs (TAGE)." TAGE is strongly associated with the onset and progression of diabetes and its vascular complications, as well as with several other conditions, including metabolic dysfunction-associated steatohepatitis (MASH), cardiovascular disease, cancer, infertility, and Alzheimer's disease. Reducing the impact of TAGE is now recognized as a potential strategy for preventing and treating lifestyle-related diseases. Additionally, fluctuations in blood TAGE levels have been identified as a promising biomarker for assessing the effectiveness of prevention, early diagnosis, and treatment of lifestyle-related diseases, including pre-disease states, regardless of diabetic status. Understanding blood TAGE levels could enable the early prediction of disease onset and progression, contributing to disease prevention and the extension of healthy life expectancy.
e-mail: 补蝉补办补蝉补颈【＠】办补苍补锄补飞补-尘别诲.补肠.箩辫
Faculty
Associate Professor
Professor Emeritus?Professor (Adjunct)
Senior Assistant Professor
Research Achievements
- Sakai-Sakasai A, Takeda K, Suzuki H, Takeuchi M: Structures of toxic advanced glycation end-products derived from glyceraldehyde, A sugar metabolite. Biomolecules 14: 202 (2024)
- Takeda K, Sakai-Sakasai A, Kajinami K, Takeuchi M: A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model. Cells. 2023; 12(24):2838.[PDF]
- Sakasai-Sakai A, Takeda K, Takeuchi M: Involvement of intercellular TAGE and the TAGE-RAGE-ROS axis in the onset and progression of NAFLD/NASH. Antioxidants 12: 748 (2023) [PDF]
- Takeuchi M, Sakasai-Sakai A et al.: Effects of toxic AGEs (TAGE) on human health. Cells 11: 2178 (2022) [PDF]
- Sakasai-Sakai A et al.: Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death. Sci. Rep. 7: 14282 (2017) [PDF]