Division of Genome Damage Response Research
Outline
Sphingolipids such as ceramide and sphingomyelin (SM) are the major components of the plasma membrane and supply the place for the ligand-receptor association regulating numerous cellular functions including proliferation, migration, cell death, inflammation, and autophagy. On the other hand, it is well-known that intracellular ceramide, which is hydrolyzed from SM, acts as the bioactive lipid inducing apoptosis or autophagy. We aim to elucidate the roles of sphingolipids in these cellular functions and their molecular mechanisms by using cells and animal models. In the future, we hope that sphingolipids and their metabolisms become the clinical and therapeutic targets for various diseases such as cancer, virus infection, and inflammation.
e-mail: 尘补迟补苍颈驳耻【＠】办补苍补锄补飞补-尘别诲.补肠.箩辫
Faculty
Professor
Senior Assistant Professor
Research Achievements
- Taniguchi M, Okazaki T “Role of sphingomyelin and its synthesis on viral lifecycle” SEIKAGAKU, 90, 173-177, 2018.
- Ohnishi T, Hashizume C, Taniguchi M, Furumoto H, Han J, Gao R, Kinami S, Kosaka T, Okazaki T “Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer” FASEB J, 31, 3816-3830, 2017.
- Taniguchi M, Tasaki T, Ninomiya H, Ueda Y, Kuremoto K, Mitsutake S, Igarashi Y, Okazaki T, Takegami T “Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus” Sci Rep, 6, 37829, 2016.
- Taniguchi N, Okazaki T “Role of ceramide and its metabolism in hematological malignancies” Hematology, 73, 478-485, 2016.
- Taniguchi M, Ogiso H, Takeuchi T, Kitatani K, Umehara H, Okazaki T “Lysososomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis” Cell Death Dis, 6, e1717, 2015.
External Research Funding
- 2017-2018: Grant-in-Aid for Young Scientists (B) from Japan Society for the Promotion of Science (JSPS), Grant Number 17K19205.
- 2013-2015: Grant-in-Aid for Young Scientists (B) from Japan Society for the Promotion of Science (JSPS), Grant Number 25870853.