Medical Research Institute - Department of Life Science
Division of Cell and Tissue Biology
Outline
The long term research interests of our group are to understand the fundamental interactions regulating essential cellular events involving RNA binding proteins at the molecular and cellular levels. We use various experimental systems incorporating biophysical, biochemical, and biological methods. Currently, the lab focuses on the regulation and localization of an RNA binding motif containing proteins and their novel function in basic cell metabolisms, such as aging, cell proliferation and gene expression. Our research area also includes the study of various inherent diseases connected to RNA and DNA metabolisms.
Contact Information
e-mail: 颈蝉丑颈驳补办颈【＠】办补苍补锄补飞补-尘别诲.补肠.箩辫
Faculty
Professor
Assistant Professor
Assistant
Research Achievements
- Ishigaki Y, Nakamura Y, Takehara T, Shimasaki T, Tatsuno T, Takano F, Ueda Y, Motoo Y, Takegami T, Nakagawa H, Kuwabata S, Nemoto N, Tomosugi N, Miyazawa S: Scanning electron microscopy with an ionic liquid reveals the loss of mitotic protrusions of cells during the epithelial–mesenchymal transition. Microsc Res Tech, 11:1024-1031 (2011)
- Ishigaki Y, Li X, Serin G, Maquat LE.: Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20, Cell, 106(5):607-617 (2001)
- Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, Onishi Y, Ozaki K, Kanayama T,Hiraiwa M, Kitaguchi Y, Kaneda K, Manabe T, Ishigaki Y, Ohno M, Hinoi E: Translational control of SOX9 RNA by mTORC1 contributes to skeletogenesis. Stem Cell Rep 11:228-241(2018)
- Tatsuno T & Ishigaki Y: C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization. Sci Rep. 8:612(2018)
- Horie T, Fukasawa K, Yamada T, Mizuno S, Iezaki T, Tokumura K, Iwahashi S, Sakai S, Suzuki A, Kubo T, Osumi R, Tomizawa A, Ochi H, Sato S, Kaneda K, Takahashi S, Hinoi E.Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood. Stem Cells. (2022)
External Research Funding
- 2017-2019：Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (JSPS), Analysis of phosphorylation regulation in TAR syndrome causative gene product Y14.
- 2016-2017：Grant-in-Aid for challenging Exploratory Research from Japan Society for the Promotion of Science (JSPS) Development of prognostic markers for glioma targeting RNA binding factors.
- 2013-2016: Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (JSPS), Regulation of nerral stem cell proliferation by RNA binding proteins.
- 2010: Project research fund from the Japanese Society of Electron Microscopy Technology for Medicine and Biology, SEM observation of biomaterials using ionic liquid.
- 2006-2009: Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (JSPS), Analysis of gene expression profile in Werner and questionable Werner syndromes.