Pathology II
Outline
Our main research projects are the investigation of molecular mechanism of invasion and metastasis of both lung cancer and bone/soft tissue sarcomas and the cytogenetic approach to tumors with FISH. We have also been doing research on several neoplastic and non-neoplastic diseases, including tissue engineering of auricular cartilage with tissue mesenchymal stem cells, steroid induced osteonecrosis and with doctoral and post-doctoral fellows from some clinical departments. We hope to integrate classic morphological pathology with novel molecular pathology by means of sophisticated experimental technologies, utilizing not only surgical materials but also cultured cells and experimental animal models with gene-modification.
e-mail: miya0807@kanazawa-med.ac.jp
Faculty
Senior Assistant Professor
Assistant Professor
Technical Assistant
TANIGUCHI Ayaka
Research Achievements
Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer.
Motono N, Ueda Y, Shimasaki M, Iwai S, Iijima Y, Usuda K, Uramoto H.
Clinical Pathology 14 1970430 2021
Glucocorticoid-induced osteocytic cell death in a hypoxic environment is associated with necroptosis
Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda
BioChem 1 98-106 2021
Resistance of bone marrow mesenchymal stem cells in a stressed environment - Comparison with osteocyte cells
Miyako Shimasaki, Shusuke Ueda, Toru Ichiseki, Hiroaki Hirata, Norio Kawahara, Yoshimichi Ueda
International Journal of Medical Sciences 18(6) 1375-1381 2021
Taurine inhibits glucocorticoid-induced bone mitochondrial injury, preventing osteonecrosis in rabbits and cultured osteocytes
Hiroaki Hirata, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Yoshimichi Ueda, Ayumi Kaneuji, Norio Kawahara
International journal of molecular sciences 21(18) 6892 2020
Mitochondrial transcription factor A added to osteocytes in a stressed environment has a cytoprotective effect
Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Hiroaki Hirata, Norio kawahara, Yoshimichi Ueda
International journal of medical sciences 17(9) 1293-1299 2020
External Research Funding
Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2019-22, to Miyako Shimasaki entitled “Elucidation of the molecular mechanism that works to prevent steroid-induced femoral necrosis by intravenous administration of mesenchymal stem cells.”
Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2014-6, to Yochimichi Ueda, entitled “Involvement of membrane sphingolipid in the invasion and metastasis of pulmonary adenocarcinoma”.
Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2011-3, to Yochimichi Ueda, entitled “Identification of aquaporins and clarification of their molecular mechanism for the metastasis and drug-resistance of bone and soft tissue sarcoma”.
Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2010-11, to Miyako Shimazaki entitled “Investigation of gene pathway playing aggressiveness of micropapillary adenocarcinoma of the lung”.
Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2009-10, to Yochimichi Ueda, entitled “Involvement of HMGA-2 and activated genes in its downstream in the progression of non-small cell lung cancer ”.