色多多视频

Departments

医学部研究室一覧のイメージ
School of Medicine - Basic Medical Science

Pharmacology

Outline

The Department of Pharmacology was established in April 1973. In June, Professor YOSHIMURA Masahiro was assigned as the first Chair of the Department. His successors have been Professor SUZUKI Shiro, Professor NISHIO Matomo, Professor ISHIBASHI Takaharu, and Professor MASUOKA Takayoshi, who has been the fifth Chair since 2021.
In research, we focus on: (1) the reception and conduction systems of nociceptive information and their regulatory mechanisms; (2) the functions of acetylcholine receptors and their contribution to neuropsychiatric disorders. Using behavioral, electrophysiological, and molecular biological techniques, we aim to elucidate novel regulatory systems in the central and peripheral nervous system and find molecular targets for drug therapy.

Contact Information
TEL: 076-218-8107 / FAX: 076-286-8191
e-mail: pharmaco@kanazawa-med.ac.jp

Faculty

Professor and Chair

Senior Assistant Professor

Senior Assistant Professor

KOBAYASHI Shizuka

Senior Assistant Professor

Secretary

OKADA Yuka

Research Achievements

Corneal acetylcholine regulates sensory nerve activity via nicotinic receptors. Takayoshi Masuoka, Takeshi Kiyoi, Shijie Zheng, Qiang He, Li Liu, Junsuke Uwada, Ikunobu Muramatsu. Ocul Surf., 32: 60-70, 2024

Voluntary wheel-running activities ameliorate depressive-like behaviors in mouse dry eye models. Katsuya Nakano, Hitomi Nakazawa, Qiang He, Junsuke Uwada, Takeshi Kiyoi, Takaharu Ishibashi, Takayoshi Masuoka. Front. Behav. Neurosci., 16: 925128, 2022

Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum. Ikunobu Muramatsu, Junsuke Uwada, Kazuyasu Chihara, Kiyonao Sada, Mao-Hsien Wang, Takashi Yazawa, Takanobu Taniguchi, Takaharu Ishibashi, Takayoshi Masuoka. J. Neurochem., 160(3): 342-355, 2022

Chronic tear deficiency sensitizes transient receptor potential vanilloid 1-mediated responses in corneal sensory nerves. Takayoshi Masuoka, Yuka Yamashita, Katsuya Nakano, Kenshi Takechi, Takahiro Niimura, Masashi Tawa, Qiang He, Keisuke Ishizawa, Takaharu Ishibashi. Front. Cell. Neurosci., 14: 598678, 2020

Sensitization of glutamate receptor-mediated pain behaviour via nerve growth factor-dependent phosphorylation of transient receptor potential V1 under inflammatory conditions. Takayoshi Masuoka, Yuka Yamashita, Junko Yoshida, Katsuya Nakano, Masashi Tawa, Matomo Nishio, Takaharu Ishibashi. Br. J. Pharmacol., 177(18): 4223-4241, 2020

External Research Funding

Kiyoi T. The Nakatomi Foundation (2022, delegate) Elucidating the mechanism of ocular side effects during S-1 cancer chemotherapy with a focus on neurogenic factors ¥1,500,000

Kiyoi T. Grant-in-Aid for Early-Career Scientists (2022-2024, delegate, 22K16960) Effects of abnormal corneal nerve excitability on ocular symptoms in cancer drug therapy side effects ¥4,550,000

Nakazawa H. Grant-in-Aid for Scientific Research (C) (2022-2024, delegate, 22K07358) Mechanism of KLK8- NRG1- ErbB signaling in spinal cord injury ¥4,160,000

Uwada J. Grant-in-Aid for Scientific Research (C) (2022-2024, delegate, 22K06637) Intracellular cholinergic transduction system demonstrated by fluorescent acetylcholine sensor ¥4,290,000

Masuoka T. Smoking Research Foundation of Japan (2021-2023, delegate, 2021G008) The underlying mechanisms leading to ocular discomfort through corneal nerves and their interactions with acetylcholine receptors and smoking ¥6,000,000

Links