Division of Cell Medicine
Outline
People tend to think of stress as a psychological phenomenon, but the cells that make up our bodies can also be exposed to various kinds of physical stress caused by internal and external factors, such as high or low temperatures, UV light, nutrient starvation, hypoxia, reactive oxygen species, and malfolded protein. Our laboratory has set a goal to understand details of cell-sensing stress and defensive response to the stress at molecular, cellular, and living organism levels. We have especially considered cellular stress as an important research target from the aspect of not only basic biology but also medical science. We are interested in the relationship between stress and lifestyle diseases, inflammation, aging, cancer, neurodegenerative disorder, fatigue, sleep, and abnormal behavior. We also make efforts for the development of model animals to monitor cellular stress in vivo.
e-mail: 颈飞补飞补办颈【补】办补苍补锄补飞补-尘别诲.补肠.箩辫
Faculty
Professor
Assistant
Research Assistant
HAMASHIMA Hisayo
Research Achievements
- Akai R, Hamashima H, Saito M, Kohno K, Iwawaki T "Partial limitation of cellular functions and compensatory modulation of unfolded protein response pathways caused by double-knockout of ATF6α and ATF6β" Cell Stress Chaperones, 29, 34-48, 2024.
- Ushimoto C, Sugiki S, Kunii K, Inoue S, Kuroda E, Akai R, Iwawaki T , Miyazawa K "Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation" Free Radic Biol Med, 207, 120-132, 2023.
- Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K "Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo" Sci Rep, 7, 46230, 2017.
- Iwawaki T, Akai R, Yamanaka S, Kohno K "Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability" Proc Natl Acad Sci USA, 106, 16657-16662, 2009.
- Iwawaki T, Akai R, Kohno K, Miura M "A transgenic mouse model for monitoring endoplasmic reticulum stress" Nat Med, 10, 98-102, 2004.
External Research Funding
- KAKENHI, Grant-in-Aid for Scientific Research (B) (2024-2026)
- KAKENHI, Grant-in-Aid for Scientific Research (B) (2021-2023)
- KAKENHI, Grant-in-Aid for Challenging Research (Exploratory) (2023-2024)
- KAKENHI, Grant-in-Aid for Scientific Research (C) (2022-2024)