Division of Systems Bioscience for Drug Discovery Based on Intrinsically Disordered Proteins
Outline
"Intrinsically disordered proteins (IDPs) are proteins that lack a fixed structure and are unstable in cytoplasm when existing alone. But once they bind with target molecules, they adopt a particular three-dimensional structure and exert their functions. We have identified the existence of a complex that has several effects in different time phases during cell division cycles, and reported that one of the components of the complex is an IDP. When its expression is inhibited, apoptosis is induced and it exerts anti-cancer effects.
Development of chemical compounds that inhibit peculiar protein-protein interactions of IDPs has been difficult and no drug has been developed yet. We aim to develop anti-cancer drugs taking a drug discovery approach targeting the IDPs, through a design using helix-loop-helix peptide and Structure Based Drug Design. Our drug discovery research areas also include intestinal flora, arteriosclerosis with age, and iron metabolism."
e-mail: 迟辞尘辞蝉耻驳颈【＠】办补苍补锄补飞补-尘别诲.补肠.箩辫
Faculty
Visiting Professor
Associate Professor(Additional Post)
Research Achievements
- Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I. Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System. Blood. 2006 Aug 15; 108(4): 1381-7.
- Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Iwabuchi K, Tomosugi N. RNA-binding protein RBM8A (Y14) and MAGOH localize to centrosome in human A549 cells. Histochem Cell Biol. 2014 Jan; 141(1): 101-9.
- Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Shimasaki T, Iwabuchi K, Tomosugi N. Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells. Exp Biol Med (Maywood). 2013 Aug 1; 238(8): 889-97.
- Ishigaki Y, Nakamura Y, Tatsuno T, Ma S, Tomosugi N. Phosphorylation status of human RNA-binding protein 8A in cells and its inhibitory regulation by Magoh. Exp Biol Med (Maywood). 2015 Apr;240(4): 438-45.
- Tomosugi N, Yamamoto S, Takeuchi M, Yonekura H, Ishigaki Y, Numata N, Katsuda S, Sakai Y. Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans. J Atheroscler Thromb. 2016 Oct 6. [Epub ahead of print]