Immunology
Outline
Welcome to our laboratory!!
In our laboratory, we are dedicated to elucidating the differentiation origin and regulatory mechanisms of dendritic cells, monocytes, and macrophages with phagocytic functions, which play central roles in immune responses. Additionally, we focus on functional analysis of mononuclear phagocytes in the onset and progression of inflammatory diseases, and strive to discover cells and molecules that could serve as molecular targets for drug development. Furthermore, we are engaged in research aimed at developing therapeutic approaches for inflammatory diseases.
e-mail: serol@kanazawa-med.ac.jp
Faculty
Professor and Chair
Assistant Professor
KOIZUMI Shinichi
Assistant
Adjunct Lecturer
Secretary
NAKAMURA Hiromi
Research Achievements
Matsuba S, Ura H, Saito F, Ogasawara C, Shimodaira S, Niida Y, Onai N. An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture. Front. Immunol., 2023, 13;14:1264609. doi: 10.3389/fimmu.2023.1264609.
Yang X, Yabe-Wada T, Han J, Saito F, Ogasawara C, Yamada S, *Onai N. PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon. Int. Immunol., 2023, doi: 10.1093/intimm/dxad003.
Kamio N, Yokota A, Tokuda Y, Ogasawara C, Nakano M, Nagao M, Tashiro K, Maekawa T, Onai N, Hirai H. A novel CD135+ subset of mouse monocytes with a distinct differentiation pathway and antigen-presenting properties. J. Immunol., 2022, 209(3):498-509.
Ohteki T, Kawamura S and Onai N. Commitment to dendritic cells and monocytes. Int. Immunol., 33:815-819, (2021).
Onai N, Asano J, Kurosaki R, Kuroda S, Ohteki T. Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments. Int. Immunol., 29: 443-456, 2017.