Physiology II
Outline
We are focusing our research interests on (1) cardiac electrophysiology, (2) the autonomic nervous system, and (3) circulatory physiology.
(1) Studies of cardiac electrophysiology are being conducted mainly by Professor and Chair Kurata. He is investigating the functions of cardiac ion channels, mechanisms of normal and abnormal automaticity, and excitation propagation in the heart using patch-clamp experiments and theoretical methods using mathematical models of cardiac myocytes.
(2) Studies of the autonomic nervous system are being conducted mainly by Dr. Tanida. He is investigating the central mechanisms of the autonomic system in rats and mice, specifically: (a) the role of autonomic nerves in metabolic syndrome and circulatory shocks, and (b) brain-gut interaction in regulations of the metabolism
(3) Studies of the pathophysiology of anaphylactic shock are being performed under the direction of Professor (Adjunct) Shibamoto, using whole animals, namely mice and rats.
In education, we give lectures and practical training on the functions of the respiratory, cardiovascular, and endocrine systems to the junior year medical students.
e-mail: physiol2@kanazawa-med.ac.jp
Faculty
Professor and Chair
Associate Professor
Associate Professor
Senior Assistant Professor
Adjunct Lecturer
Research Achievements
Tanida M, Zhang T, Sun L, Song J, Yang W, Kuda Y, Kurata Y, Shibamoto T. Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c-fos in the hypothalamus and medulla oblongata. Experimental Physiology 103:790-806, 2018.
Yang W, Shibamoto T, Kuda Y, Zhang T, Tanida M, Kurata Y. β2-adrenoceptor blockade deteriorates systemic anaphylaxis by enhancing hyperpermeability in anesthetized mice. Allergy Asthma & Immunology Research, 10:52-61, 2018.
Kuda Y, Shibamoto T, Zhang T, Yang W, Tanida M, Kurata Y. Gastric vascular and motor responses to anaphylactic hypotension in anesthetized rats, in comparison to those with hemorrhagic or vasodilator-induced hypotension. Journal of Physiological Sciences 68:253-260, 2018.
Tsumoto K, Kurata Y, Furutani K, Kurachi Y. Hysteretic dynamics of multi-stable early afterdepolarisations with repolarisation reserve attenuation: a potential dynamical mechanism for cardiac arrhythmias. Scientific Reports 7:10771, 2017.
Kurata Y, Tsumoto K, Hayashi K, Hisatome I, Tanida M, Kuda Y, Shibamoto T. Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models. American Journal of Physiology-Heart and Circulatory Physiology 312:H106-H127, 2017.
External Research Funding
Kurata Y. Grant-in-Aid for Scientific Research (C) (2019-2022, delegate) Establishment and demonstration of myocardial system control theory using cultured HL-1 cardiomyocytes and its mathematical model, ￥3,300,000.
Shibamoto T. Grant-in-Aid for Scientific Research (C) (2019-2021, delegate) Elucidation of the generation mechanism of anaphylactic shock biphasic reaction using noninvasive thermography, ￥3,300,000.
Kuda Y. Grant-in-Aid for Early-Career Scientists (2018-2021, delegate) Elucidation of generation and suppression mechanisms in afterdepolarization-mediated arrhythmias using the experimental system of cultured HL-1 atrial myocytes, ￥3,200,000.
Tanida M. Grant-in-Aid for Scientific Research (C) (2016-2019, delegate) Studies on the mechanism for the activation of the sympathetic nervous system of the adipose tissue by nesfatin-1. ￥3,600,000.
Tanida M. KIEIKAI RESEARCH FOUDATION (2018, delegate) Elucidation of the facilitating mechanism of a sympathetic nerve by anaphylactic hypotension and application to therapy, ￥2,000,000.