Anatomy I
Outline
The unique leukemia inhibitory factor (LIF) signal pathway between mother and fetuses have been identified in rodents (Simamura et al., 2010). The maternal LIF signals induce adrenocorticotropic hormone (ACTH) from the placenta, which in turn induces LIF secretion from nucleated erythroblasts of fetuses. Finally, LIF of fetal origin contributes to the brain development and erythropoiesis. In our laboratory, details of the molecular mechanisms and its physiological functions have been extensively investigated. Then, we have investigated the interaction between an failure of this maternal-fetal signal relay of LIF and a risk of prenatal origin of autism, schizophrenia or bipolar disorder.
We have developed the new method for making biological specimens (brain, lung, intestine, other organs, whole embryos, etc.) transparent to observe the internal structures. Using this technique, details of GFP expressing cells in the deep area can be detected. Whole mount bone staining of small fishes (medaka, zebra fishes), frogs (Xenopus laebis) or mouse and rat fetuses are rapidly completed with this technique.
e-mail: 迟丑补迟迟补【补】办补苍补锄补飞补-尘别诲.补肠.箩辫（【补】=蔼）
Faculty
Professor and Chair
Professor Emeritus
Associate Professor
Assistant Professor
笔谤辞蹿别蝉蝉辞谤（狈耻谤蝉颈苍驳)
Project Technician
础厂础碍鲍搁础 驰辞蝉丑颈丑耻尘颈
Secretary
YASUDA Tomoko
Research Achievements
- Yo Shimizu, Hiromi Sakata-Haga, Yutaka Saikawa and Toshihisa Hatta：Influence of Immune System Abnormalities Caused by Maternal Immune Activation in the Postnatal Period：Cells 2023, 12(5), 741
- Daisuke Sakai, Takeru Sugawara, Tomonori Kurokawa, Yuki Murakami, Mitsuhiro Tomosugi, Hiroko Masuta, Hiromi Sakata Haga, Toshihisa Hatta and Hiroki Shoji：Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model： Molecular Brain volume 15, Article number: 28 (2022)
- Sho Takata, Hiromi Sakata-Haga, Hiroki Shimada, Tsuyoshi Tsukada, Daisuke Sakai, Hiroki Shoji, Mitsuhiro Tomosugi, Yuka Nakamura, Yasuhito Ishigaki, Hideaki Iizuka, Yasuhiko Hayashi and Toshihisa Hatta：LIF–IGF Axis Contributes to the Proliferation of Neural Progenitor Cells in Developing Rat Cerebrum：Int. J. Mol. Sci. 2022, 23(21), 13199
- Nobuo Kariyama, Hiromi Sakata Haga , TsuyoshiTsukada, Hiroki Shimada , MakotoTaniguchi & Toshihisa Hatta：Rapid bone staining with hair removal (RAP B/HR): a non destructive and rapid whole mount bone staining protocol optimized for adult hairy mice：Scientifc Reports | (2021) 11:1950
- Yo Shimizu ,Tsuyoshi Tsukada , Hiromi Sakata-Haga , Daisuke Sakai , Hiroki Shoji , Yutaka Saikawa, Toshihisa Hatta ：Exposure to Maternal Immune Activation Causes Congenital Unfolded Protein Response Defects and Increases the Susceptibility to Postnatal Inflammatory Stimulation in Offspring：Journal of Inflammation Research 2021:14 355–365
External Research Funding
- Grant-in-Aid for Scientific Research(B)
- JSPS KAKENHI Grant Number 22HT0093
- Grant-in-Aid for Scientific Research(C) (21K12258)
- JSPS KAKENHI Grant Number 21HT0119
- JSPS KAKENHI Grant Number 20HT0143