Biochemistry II
Outline
Education:
The Department of Biochemistry II takes charge of the lectures and laboratories on biochemistry and molecular biology for the first- and second-year medical students.
Research:
Our major research projects are:
1. Molecular mechanisms of the regulation of vascular network formation.
2. Roles and molecular basis of neuro-vascular interactions.
3. Mechanisms of regulation of alternative pre-mRNA processing.
4. Molecular mechanisms of development of eye diseases.
Please see the references listed below.
e-mail: biochem2@kanazawa-med.ac.jp
Faculty
Professor and Chair
Associate Professor
Senior Assistant Professor
Assistant Professor
Research Achievements
Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H. Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition. Biol Open. 18;8(2):bio035691 (2019)
Yoshitomi Y, Ikeda T, Saito H, Yoshitake Y, Ishigaki Y, Hatta T, Kato N, Yonekura H. JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin. J Cell Sci. 1;130(5):916-926 (2017)
Ikeda T, Yoshitomi Y, Saito H, Shimasaki T, Yamaya H, Kobata T, Ishigaki Y, Tomosugi N, Yoshitake Y, Yonekura H. Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation. Mol. Cell. Biochem. 413(1-2): 155-164 (2016)
Ikeda T, Sun L, Tsuruoka N, Ishigaki Y, Yoshitomi Y, Yoshitake Y, Yonekura H. Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing. Biochem. J. 436 (2):399-407 (2011)
Osada H, Yoshitake Y, Ikeda T, Ishigaki Y, Takata T, Tomosugi N, Sasaki H, Yonekura H. Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells. Mol. Vis. 17:159-169 (2011)
External Research Funding
JSPS KAKENHI Grant Number 21K09031 (Grant-in-Aid for Scientific Research (C)，Takayuki Ikeda, 2021～2023, The role of sFlt-1 (sVEGFR-1) produced by endothelial cells in sepsis.)
JSPS KAKENHI Grant Number 19K07407 (Grant-in-Aid for Scientific Research (C)，Hideto Yonekura, 2019～2022, The role of Otx2 induced in lens by UV exposure in cataract development.)
JSPS KAKENHI Grant Number 18K06924 (Grant-in-Aid for Scientific Research (C)，Yasuo Yoshitomi, 2018～2020, Analysis of JunB-related cell-cell signaling for neurovascular parallel alignment.)
JSPS KAKENHI Grant Number 17K15607 (Grant-in-Aid for Young Scientists (B)，Hidehito Takatsuji-Saito, 2017～2020, Molecular mechanisms of vasculogenic mimicry in high-metastatic Lewis lung carcinoma.)
JSPS KAKENHI Grant Number 24790297 (Grant-in-Aid for Young Scientists (B)，Yasuo Yoshitomi, 2012～2015, Novel functions of JunB in the vascular network development via neuro-vascular interactions.)