School of Medicine - Basic Medical Science
Physiology I
Outline
Our core competence is to investigate properties of cortical neurons, including channel functions and synaptic plasticity, by using electrophysiological methods. We have so far elucidated novel modes of channel coupling that constitute negative or positive feedback regulations of neuronal excitability. Interestingly, some of these regulation mechanisms are reasonably related with the pathophysiology of major depression and Alzheimer’s disease. By relying on molecular biological methods as well, we started collecting evidence that could link neurophysiological and behavioral variables in the context of these neuropsychiatric disorders, so as to find out new vistas of yet unknown therapeutics.
Contact Information
TEL: 076-218-8102
/ FAX: 076-286-3523
e-mail: physiol1@kanazawa-med.ac.jp
e-mail: physiol1@kanazawa-med.ac.jp
Faculty
Professor
Professor
Associate Professor
Assistant Professor
Research Achievements
- Tajima N, Liu X, Taniguchi M, Kato N. 24S-hydroxycholesterol alters activity of large-conductance Ca2+-dependent K+ (slo1 BK) channel through intercalation into plasma membrane. (2019)BBA Lipids In press
- Ono M, Muramoto S, Ma L, Kato N. Optogenetics identification of neuronal type in awake mice with a glass optrode. Journal of Visualized Experiments. Jun 28; (136). 2018.
- Yamamoto R, Ahmed N, Ito T, Gungor NZ, Paré D. Optogenetic study of anterior BNST and basomedial amygdala projections to the ventromedial hypothalamus. eNeuro 5, 3, 0204-18 (2018).
- Wang M, Uchiumi O, Ogiso H, Shui Y, Zou J, Hashizume C, Taniguchi M, Okazaki T, Kato N. Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice. Behav Brain Res, 319: 25-30. (2017).
- Zou J, Wang M, Uchiumi O, Shui Y, Ishigaki Y, Liu X, Tajima N, Akai T, Iizuka H, Kato N. Learning impairment by minimal cortical injury in a mouse model of Alzheimer’s disease. Brain Res, 1637: 56-63. (2016).
External Research Funding
- KAKENHI（Grants-in-Aid for Scientific Research) Grant-in-Aid for Scientific Research (B) (17H02223)
- KAKENHI（Grants-in-Aid for Scientific Research) Grant-in-Aid for Scientific Research (C) (19K09918)
- KAKENHI（Grants-in-Aid for Scientific Research) Grant-in-Aid for Scientific Research (C) (18K07572)
- Fund for the Promotion of Joint International Research, Fostering Joint International Research (A) (18KK0468)
- KAKENHI（Grants-in-Aid for Scientific Research) Grant-in-Aid for Early-Career Scientists (19K19808)