General Internal Medicine
Outline
The Department of General Internal Medicine focuses on holistic treatment by comprehensively understanding organ function, physical function, and social background, transcending the traditional boundaries of specializations within internal medicine. Our goal is to generate evidence that can be broadly applied in clinical practice by planning, conducting, analyzing, and interpreting research in collaboration with experts across various fields, both within and outside the university. We also engage in research on standardized medical planning, multidisciplinary team-based care, health care services, and health economics, all of which are essential competencies for medical practice in the 21st century. We aim to train professionals who possess the knowledge and skills of general internists with broad insight into all areas of internal medicine. Additionally, we aim to develop "Staff physicians" with a comprehensive understanding of patient backgrounds, capable of providing holistic care in collaboration with multidisciplinary medical teams.
Our research focuses on the following areas:
1. Developing appropriate treatment methods based on a comprehensive patient background assessment
2. Diagnosis and treatment of diseases using molecular genetic information
3. Development of tailor-made therapies for malignant disease
4. Comprehensive search for predictors of the development of sarcopenia in chronic diseases
5. Molecular genetic elucidation of the effects of chronic inflammation on blood vessels and organs
We also manage the General Medicine Center within the Multidisciplinary Centers of 色多多视频 Hospital, supervising the outpatient clinics for Lifestyle-related Diseases, Kampo Medicine (Japanese herbal medicine), as well as the Women's Health Center.
In the field of lifestyle-related diseases, we promote research focusing on metabolic syndrome, obesity, dyslipidemia, diabetes, and hypertension. We employ the InBody (body composition analyzer) and the dual-impedance method to evaluate cases of suspected visceral fat accumulation, and we conduct epidemiological studies on dyslipidemia, which is closely linked to the development of atherosclerotic diseases such as familial hypercholesterolemia (FH). Additionally, we investigate the dynamics of lipid metabolic enzymes as predictors of cardiovascular events.
In Kampo medicine research, we are developing mouse models for chronic fatigue to analyze the disease’s pathogenesis. We mainly focus on the central nervous system, particularly functional and mobility changes in the hippocampus. Our future goals include clarifying the pathology and establishing biomarkers by performing immunostaining and PCR analysis for various organs.
The Department of Women's Health aims to establish a new approach to gender-specific medicine by supporting female doctors and promoting team-based outpatient care for women, particularly in response to community healthcare challenges.
e-mail: general@kanazawa-med.ac.jp
Faculty
Professor and Chair
Professor
Professor
Professor
Professor
Associate Professor
Assistant Professor
Research Achievements
Ueda Y, Sakai T, Yamada K, Arita K, Ishige Y, Hoshi D, Yanagisawa H, Iwao-Kawanami H, Kawanami T, Mizuta S, Fukushima T, Yamada S, Yachie A, Masaki Y. Fatal hemophagocytic lymphohistiocytosis with intravascular large B-cell lymphoma following coronavirus disease 2019 vaccination in a patient with systemic lupus erythematosus: an intertwined case. Immunol Med. 2024 Apr 15:1-8.
Hirabayashi S, Kondo T, Nishiwaki S, Mizuta S, Doki N, Fukuda T, Uchida N,Ozawa Y, Kanda Y, Imanaka R, Takahashi S, Ishikawa J, Yano S, Nakamae H, Eto T, Kimura T, Tanaka J, Ichinohe T, Atsuta Y, Kako S. Impact of MRD on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph+ALL: A retrospective nationwide study. Am J Hematol. 2023 Oct;98(10):1606-1618.
Mizuta S, Ugai T, Kato H, Doki N, Ota S, Kawakita T, Katayama Y, Kurokawa M, Nakamae H, Yano S, Nawa Y, Kanda Y, Fukuda T, Atsuta Y, Kako S. Propensity score matching/reweighting analysis comparing autologous and allogeneic stem cell transplantation for B-lineage acute lymphoblastic leukemia. Int J Hematol. 2022 Sep;116(3):393-400.
Masuda T, Maeda S, Shimada S, Sakuramoto N, Morita K, Koyama A, Suzuki K, Mitsuda Y, Matsuo H, Kubota H, Kato I, Tanaka K, Takita J, Hirata M, Kataoka TR, Nakahata T, Adachi S, Hirai H, Mizuta S, Naka K, Imai Y, Kimura S, Sugiyama H, Kamikubo Y. RUNX1 transactivates BCR-ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia. Cancer Sci. 2022 Feb;113(2):529-539.
Nishiwaki S, Mizuta S, Ohashi K, Fukuda T, Uchida N, Tachibana T, Onizuka M, Ozawa Y, Onishi Y, Takahashi S, Eto T, Nakamae H, Tanaka J, Ichinohe T, Atsuta Y, Kako S; Adult Acute Lymphoblastic Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation. Different impact of BCR-ABL transcripts on allogeneic hematopoietic cell transplantation from different graft sources for Ph?+?ALL with minimal residual disease. Am J Hematol. 2019 Nov;94(11):E301-E305.
External Research Funding
Sciences Research Grant Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research ‘The clarification of measuring lipid metabolism enzymes as predictors of cardiovascular events” (2015-2017)
Sciences Research Grant Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research “The clarification of measuring lipid metabolism enzymes as predictors of the development of non-alcoholic steatohepatitis” (2011-2013)
Sciences Research Grant for Young Scientists (B) “Revitalization of the central nervous system in Chinese medicine treatment of Chronic Fatigue Syndrome”(2008-2010)
Sciences Research Grant Grant-in-Aid for Scientific Research (C) “Analysis of the effect of Boiogito on the metabolic syndrome “ (2006)